Systemic immune inflammation index: is it a new marker for contrast-induced nephropathy?

Introduction: Worldwide, >200 million patients are affected by peripheral arterial disease (PAD) and endovascular interventional treatments increasingly being applied. Contrast-induced nephropathy (CIN) is the third most common cause of renal failure in hospitals. However, factors such as vasoconstriction, decrease blood flow, endothelial dysfunction, oxidative stress have been suggested etiology CIN. Studies showing that inflammatory markers increase Systemic immune inflammation index (SII), a newly defined parameter, calculated multiplying platelet lymphocyte counts dividing neutrophil count. this parameter influences prognosis various cancer types. Considering may play role CIN, we planned study to investigate SII undergoing percutaneous vascular interventions. Material Method: 300 who underwent interventions between August 2018-December 2021 due were included study. The data scanned retrospectively from patient files. neutrophil-lymphocyte ratio (NLR) was count found NLR with Results: developed 41 (12.3%) patients. CIN(+) also, had higher CRP levels (5.1±0.7vs 2.4±0.4,P<0.05), (4.07±1.07vs 2.65±0.84, P<.005), score (1778±627.57vs 867.14±491.88, P<.005.) contrast media used also (176.19±48.44 vs 128.72±48.44;P<0.05) Multivariate logistic regression analysis demonstrated high an independent predictor development CIN (odds [OR]: 1.002, 95% confidence interval [CI]: 1.001-1.002, P<.0005) together (OR: 3.56, CI: 1.905-6.675, P<.005) P<.005 Receiver operating characteristic curve best cutoff value 1224 for predict 85% sensitivity 72% specificity (area under ROC 0.904 [95% 0.866-0.942], P<.005). Conclusion: Imbalance cells, neutrophils, lymphocytes developing kidney damage. Impaired functions lymphocytopenia contribute acute injury. Oxidative exacerbates state increasing cell infiltration. AS result, be powerful can determine risk before procedures.